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Instances of diflucan fatal hepatic reactions were noted to effects occur primarily in diflucan patients with serious underlying medical conditions (predominantly aids or malignancy ) and often while taking multiple concomitant medications. In 422 patients receiving active comparative side agents, the incidence was. Certain other drugs can cause unwanted or dangerous effects when used with Diflucan, especially cisapride, erythromycin, pimozide, and quinidine. Ref Rare (less than.1 Anaphylactic reaction, anaphylaxis Frequency not reported : Hypersensitivity reactions (including generalized edema, side stridor, hypotension, exfoliative dermatitis, ulcerative eruptions fixed drug diflucan eruption Postmarketing reports : Anaphylaxis (including angioedema, face edema, pruritus) Ref Cardiovascular Most reports. Before taking this medicine, you should not use. In rare cases, patients treated with Diflucan may develop dangerous heart rhythm abnormalities or serious allergic reactions. Store the tablets at room temperature away from side moisture and heat. She did not admit to taking fluconazole. Ref Very common (10 or more Increased ALT, increased side AST Uncommon (0.1 to 1 Serum transaminase elevations, cholestasis, jaundice, increased bilirubin Rare (less than.1 Serious hepatic reactions, hepatic toxicity (including fatalities hepatic failure, hepatocellular necrosis, hepatitis, hepatocellular damage Frequency. Diflucan is also used to prevent fungal infection in people who effects have a weak immune system caused by cancer treatment, bone marrow transplant, or diseases diflucan such as, aIDS. Diflucan if you are allergic to fluconazole. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less Common Belching change in taste or bad, unusual, or unpleasant (after) taste heartburn indigestion. In Phase II/III clinical trials conducted in the United States and in Europe, 577 pediatric patients, ages 1 day to 17 years were treated with diflucan at doses up to 15 mg/kg/day for up to 1,616 days. Copyright Cerner Multum, Inc. Pappas PG, Kauffman CA, Perfect J, Johnson PC, Mckinsey effects DS, Bamberger DM, Hamill R, Sharkey PK, Chapman SW, Sobel JD "Alopecia associated with fluconazole effects therapy." Ann Intern Med 123 (1995 354-7. Jacobson MA, Hanks DK, Ferrell effects LD "Fatal acute hepatic necrosis due to fluconazole." Am J Med 96 (1994. Goodman JL, Winston DJ, Greenfield RA, et al "A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation." N Engl J Med 326 (1992. Agarwal A, Sakhuja V, Chugh KS "Fluconazole-induced thrombocytopenia." Ann Intern Med 113 (1990 899. Diflucan has been used in the pediatric population, but its dose is determined by pediatric patient weight ranges and a mg/Kg sliding scale. Ref Genitourinary Uncommon (0.1 to 1 Intermenstrual bleeding, dysmenorrhea, leukorrhea, menorrhagia, uterine spasm, vaginal disorders, female sexual dysfunction Respiratory Uncommon (0.1 to 1 Pharyngitis Frequency not reported : Respiratory disorders Ref Ocular Uncommon (0.1 to 1 Abnormal vision References. Diflucan is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, side bladder, genital area, and the blood. Mercurio MG, Elewski BE "Thrombocytopenia caused by fluconazole therapy." J Am Acad Dermatol 32 (1995 525-6. Treatment was discontinued.5 of patients due to adverse effects clinical events and.3 of patients due to laboratory test abnormalities. Pappas PG, Kauffman CA, Sobel JD "Alopecia associated with fluconazole therapy." Ann Intern Med 125 (1996 153-4. Mercurio MG, Elewski BE "Thrombocytopenia caused by fluconazole - reply." J Am Acad Dermatol 35 (1996 284. Diflucan ) may cause some unwanted effects. Acute generalized exanthematous pustulosis, drug eruption, increased sweating, exfoliative skin disorders (including Stevens-Johnson syndrome, toxic epidermal necrolysis and alopecia have also been reported during postmarketing experience. Carefully follow your doctor's instructions. See below for a comprehensive list of adverse effects. Diflucan (fluconazole)." Roerig Division, New York,. In each of these cases, liver function returned to baseline on discontinuation of diflucan. A causal relationship to drug exposure could not be determined. Call your doctor at once if you have: fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out fever, chills, body aches, flu symptoms; easy bruising or bleeding, unusual weakness; seizure. De Wit S, Clumeck N "Fluconazole in the treatment of fungal infections associated with aids." effects Infection 17 (1989 121-3. Adverse Reactions side In Children The pattern and incidence of adverse events and laboratory abnormalities recorded during pediatric clinical trials are comparable to those seen in adults. Follow all directions on your prescription label and read all medication guides or instruction sheets. Some side effects may not be reported. During clinical trials of single-dose therapy, side effects possibly related to therapy were reported in 26 of patients using this drug and 16 of patients using active comparative agents. Over the subsequent 36-hours, the patient remained in sinus rhythm except for one brief run of ventricular bigeminy. Transaminase elevations greater than 2 to 3 x ULN have also been reported. Most side effects were of mild to moderate severity. Wells C, Lever AM "Dose-dependent fluconazole hepatotoxicity proven on biopsy and rechallenge." J Infect 24 (1992 111-2. In some patients, particularly those with serious underlying diseases such as aids and cancer, changes in renal and hematological function test results and hepatic abnormalities have been observed during treatment with fluconazole and comparative agents, but the clinical significance and relationship to treatment is uncertain. Within 12 hours, she noticed 3 oval, painful, eroded, pigmented patches over her trunk with diameters of 3 to 4 cm and erythematous halos.

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